Genomics and predictive medicine

نویسندگان

چکیده

Progress in understanding of structural and functional human genome organization deciphering primary DNA sequence cells allowed for hitherto unreachable new capabilities medical genetics identifying the causes mechanisms inherited inborn pathology. Implementation into medicine is progressively advancing along with improvement molecular analysis genome. Knowledge its functions allows to provide more accurate diagnosis, predict, a considerable extent, presence genetic predisposition person pathology, assess chances developing one or another disease. This approach became basis area named predictive medicine. The progress refl ects success tremendous upgrowth methods studying structure Within less than 15 years after genome, has travelled long way from single gene whole studies, screening associations systems multifactorial diseases, translational high-precision genetics, passport idea electronic health records. development passport, prognostic testing, genomic chart reproductive especially relevant current practical

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Hypothesis-generating clinical genomics research and predictive medicine

The advent of affordable genome and exome sequencing provides incredible opportunities and poses significant challenges for clinical research and clinical care. For the first time, it is technically feasible to access the entire genetic architecture of a phenotype. The dissection of this genetic architecture of disease will yield unprecedented insights into molecular pathophysiology and provide...

متن کامل

Traditional medicine and genomics

'Omics' developments in the form of genomics, proteomics and metabolomics have increased the impetus of traditional medicine research. Studies exploring the genomic, proteomic and metabolomic basis of human constitutional types based on Ayurveda and other systems of oriental medicine are becoming popular. Such studies remain important to developing better understanding of human variations and i...

متن کامل

Pharmacogenetics/genomics and personalized medicine.

Despite the marked advances in drug therapy, some patients do not respond favorably or suffer severe adverse drug effects. Pharmacogenetic studies have shown that polymorphisms of drug metabolizing enzymes, transporters and receptors contribute to variable drug response. Owing to the complexity of drug actions, a broader genomics approach aims at finding new drug targets and optimizing therapy ...

متن کامل

Predictive genomics of cardioembolic stroke.

Cardioembolic stroke is a complex disease resulting from the interaction of numerous factors. Using data from Genes Affecting Stroke Risk and Outcome Study (GASROS), we show that a multivariate predictive model built using Bayesian networks is able to achieve a predictive accuracy of 86% on the fitted values as computed by the area under the receiver operating characteristic curve relative to t...

متن کامل

Integrative genomics in cardiovascular medicine.

Integrative genomics studies have greatly advanced our understanding of cardiovascular pathophysiology over the last decade. Here, we highlight the strengths and challenges of this cutting-edge approach and provide examples where novel insights have arisen through the integration of multi-level genomic information and cardiac physiology. Going forward, the integration of comprehensive next-gene...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Sibirskij žurnal klini?eskoj i èksperimental?noj mediciny

سال: 2021

ISSN: ['2713-265X', '2713-2927']

DOI: https://doi.org/10.29001/2073-8552-2021-36-4-14-28